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Study Single-Cell Interactions with

Unprecedented Throughput and Precision

Scribe Biosciences is an early-stage company pioneering technologies to accelerate immunotherapy discoveries through linked functional and genomic profiling of single-cell interactions. 

 
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Technology

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  • Scribe Biosciences was established from technologies developed at the University of California, San Francisco to build droplet microfluidic assays with precise cell ratios.

  • Scribe's core technology, Microenvironment on Demand (MOD), enables the construction of hundreds of thousands of live cell-based assays (cytotoxicity, secretion) in droplets and selectively profile assay-positive droplets using genomics readouts.

  • MOD will enable deeper understanding of cancer, heart and autoimmune diseases by linking live-cell assays to genomics at a single-cell resolution.

Publications

1. Printed droplet microfluidics for on-demand dispensing of picoliter droplets and cells, R.H. Cole, S. Tang , C. A. Siltanen , P. Shahi , J.Q. Zhang, S. Poust , Z.J. Gartner and A.R. Abate. PNAS August 15, 2017 114 (33) 8728-8733.

 

2. An Oil-Free Picodrop Bioassay Platform for Synthetic Biology, C.A. Siltanen, R.H. Cole, S. Poust, L. Chao, J. Tyerman, B. Kaufmann-Malaga, J. Ubersax, Z.J. Gartner, and A.R. Abate. Scientific Reports, 2018, 8, Article number: 7913.

 

3. Linked optical and gene expression profiling of single cells at high-throughput, Zhang, J.Q., Siltanen, C.A., Liu, L., Chang, K.C., Gartner, Z.J. and Abate, A.R. Genome Biology, 2020, 21, Article number: 49.

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4. Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs). Madrigal JL, Schoepp NG, Xu L, Powell CS, Delley CL, Siltanen CA, Danao J, Srinivasan M, Cole RH, Abate AR. PNAS, DOI: 10.1073/pnas.2110867119

 
 
 
 

Job Opportunities

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953 Indiana St.

San Francisco, CA 94107 

Email: info@scribebiosciences.com

Please drop us a line. We are actively seeking out collaboration and pilot project opportunities.