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Scribe Biosciences Wins CYTO 2022 Technology Showcase

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Study Single-Cell Interactions with

Unprecedented Throughput and Precision

Scribe Biosciences is an early-stage company pioneering technologies to accelerate immunotherapy discoveries through linked functional and genomic profiling of single-cell interactions.

Who are we

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Technology

Scribe Biosciences was established from technologies developed at the University of California, San Francisco to build droplet microfluidic assays with precise cell ratios.

Scribe's core technology, Microenvironment on Demand (MOD), enables the construction of hundreds of thousands of live cell-based assays (cytotoxicity, secretion) in droplets and selectively profile assay-positive droplets using genomics readouts.

MOD will enable deeper understanding of cancer, heart and autoimmune diseases by linking live-cell assays to genomics at a single-cell resolution.

Publications

1. Printed droplet microfluidics for on-demand dispensing of picoliter droplets and cells, R.H. Cole, S. Tang , C. A. Siltanen , P. Shahi , J.Q. Zhang, S. Poust , Z.J. Gartner and A.R. Abate. PNAS August 15, 2017 114 (33) 8728-8733.

2. An Oil-Free Picodrop Bioassay Platform for Synthetic Biology, C.A. Siltanen, R.H. Cole, S. Poust, L. Chao, J. Tyerman, B. Kaufmann-Malaga, J. Ubersax, Z.J. Gartner, and A.R. Abate. Scientific Reports, 2018, 8, Article number: 7913.

3. Linked optical and gene expression profiling of single cells at high-throughput, Zhang, J.Q., Siltanen, C.A., Liu, L., Chang, K.C., Gartner, Z.J. and Abate, A.R. Genome Biology, 2020, 21, Article number: 49.

4. Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs). Madrigal JL, Schoepp NG, Xu L, Powell CS, Delley CL, Siltanen CA, Danao J, Srinivasan M, Cole RH, Abate AR. PNAS, DOI: 10.1073/pnas.2110867119

Technology

How it works

Team

Russell Cole, PhD

CEO/Co-Founder

Ian Walton
Sr. VP of Engineering

Zev Gartner, PhD
Advisor/Co-Founder

Adam Abate, PhD
Advisor/Co-Founder

Justin Madrigal, PhD
Director, Applications

Nathan Schoepp, PhD
Director, Chemistry

Bill Hyun, PhD

Investor

Paul McEwan

Investor

Lawrence Fong, MD
Scientific Advisor

Codian Powell, M.S.
Associate Scientist

Philip Thomas, Ph.D.
Engineer

Alyssa Amezquita
Associate Scientist

CONTACT

Job Opportunities

Job Opportunities

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953 Indiana St.

San Francisco, CA 94107

Email: info@scribebiosciences.com

Please drop us a line. We are actively seeking out collaboration and pilot project opportunities.

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