Study Single-Cell Interactions with
Unprecedented Throughput and Precision
Scribe Biosciences is an early-stage company pioneering technologies to accelerate immunotherapy discoveries through linked functional and genomic profiling of single-cell interactions.
Scribe Biosciences was established from technologies developed at the University of California, San Francisco to build droplet microfluidic assays with precise cell ratios.
Scribe's core technology, Microenvironment on Demand (MOD), enables the construction of hundreds of thousands of live cell-based assays (cytotoxicity, secretion) in droplets and selectively profile assay-positive droplets using genomics readouts.
MOD will enable deeper understanding of cancer, heart and autoimmune diseases by linking live-cell assays to genomics at a single-cell resolution.
1. Printed droplet microfluidics for on-demand dispensing of picoliter droplets and cells, R.H. Cole, S. Tang , C. A. Siltanen , P. Shahi , J.Q. Zhang, S. Poust , Z.J. Gartner and A.R. Abate. PNAS August 15, 2017 114 (33) 8728-8733.
2. An Oil-Free Picodrop Bioassay Platform for Synthetic Biology, C.A. Siltanen, R.H. Cole, S. Poust, L. Chao, J. Tyerman, B. Kaufmann-Malaga, J. Ubersax, Z.J. Gartner, and A.R. Abate. Scientific Reports, 2018, 8, Article number: 7913.
3. Linked optical and gene expression profiling of single cells at high-throughput, Zhang, J.Q., Siltanen, C.A., Liu, L., Chang, K.C., Gartner, Z.J. and Abate, A.R. Genome Biology, 2020, 21, Article number: 49.
4. Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs). Madrigal JL, Schoepp NG, Xu L, Powell CS, Delley CL, Siltanen CA, Danao J, Srinivasan M, Cole RH, Abate AR. PNAS, DOI: 10.1073/pnas.2110867119